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FDA Warning Regarding Type2 Diabetes Drug Invokana

Two clinical trials of Type2 diabetics taking Johnson & Johnson’s diabetes drug, Invokana, also known also as canagliflozin, have revealed that users are twice as likely to suffer foot and leg amputations than those given a placebo. The U.S. Food and Drug Administration is requiring Johnson & Johnson to add new warnings about the risk of foot and leg amputations to Invokana.
Invokana is a type of relatively new class of Type2 diabetes drugs called SGLT-2 inhibitors. These drugs remove excess blood sugar through the urine. It is not known yet what effect this will have on kidneys. The body naturally removes excess blood sugar through the urine- referred to as “spilling sugar.” This is known to cause complications. What is known is that it is better to prevent high blood sugar levels, rather than to compensate for them by spilling sugar in the urine. Others in this class of SGLT-2 inhibitors include Jardiance (Eli Lilly & Co.) and Farxiga (AstraZeneca Plc.)
FDA Warning

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About The Author

Picture of Leslie A. Goller

Leslie A. Goller

Leslie has dedicated her career to championing consumers – whether they were harmed by big corporations, dangerous products, medical mistakes, accidents, or an unsafe environment – no issue is too big for her to tackle. She successfully prevented an incinerator from being built at University Hospital (now UF-Jacksonville), which would have polluted the air with toxic chemicals and obtained significant restrictions of other Jacksonville hospital incinerators resulting in cleaner air.